NOAC-Drug Interactions Linked to Increased Bleeding

Bleeding risk with the new oral anticoagulant drugs (NOACs) is increased when they are used with some other medications, including amiodarone, often co-prescribed with these agents, a new study warns.
The study, published in the October 3 issue of JAMA, found that among patients taking NOACs for nonvalvular atrial fibrillation, concurrent use of amiodarone, fluconazole, rifampin, and phenytoin was associated with increased risk for major bleeding compared with the use of NOACs alone.
But atorvastatin, which like the other drugs studied shares key metabolic pathways with NOACs, did not show an increased bleeding risk when combined with a NOAC and was actually associated with a lower risk than a NOAC alone.
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