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Washington: Scientists have used a gene editing tool to disrupt a mutation responsible for some forms of glaucoma, an advance that could help prevent one of the most common causes of irreversible blindness in humans.
A team led by researchers from the University of Iowa in the US eliminated mutated myocilin protein from a mouse model of human glaucoma and cultured human cells through the use of CRISPR-Cas9, which can alter DNA sequences and gene function. Mutations in myocilin are implicated in juvenile- and adult-onset primary open-angle glaucoma.
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